Fresh analysis suggests that patients who come off new slimming jabs like Mounjaro or Wegovy can put back on reduced body mass at a significantly accelerated pace than those who stop traditional lifestyle plans.
Findings released in a leading medical journal shows that while overweight individuals can lose a large proportion of their total mass while using the jabs, the weight comes back at an average rate of 0.8 kg per month once they quit.
"Individuals purchasing these treatments must be aware of the potential of quick rebound weight gain when the treatment is stopped," warns lead investigator Dr. Susan Jebb.
This pace of regain suggests a return to original mass in about 18 months.
Comparing Approaches
The study, which looked at dozens of studies involving over 9,000 of participants, compared the effects of these new drugs with conventional dieting.
The team point out that people who shed pounds through lifestyle changes alone usually see a more gradual weight regain—approximately 100 grams monthly—post-intervention.
The Reason for the Rapid Rebound
Nutrition scientists propose the way of the drugs accounts for the accelerated rebound.
These medications imitate a natural hormone called glucagon-like peptide-1, which helps regulate appetite.
"Sustained high doses of GLP-1 levels far above than the body's typical production may cause the system to produce less of its endogenous GLP-1, and may also reduce sensitivity to its actions," said Dr. Adam Collins, a dietetics researcher.
"Stopping of this medication results in appetite is unsuppressed, making excessive eating a significant risk."
A Chronic Disease?
The NHS recommend the jabs for individuals with obesity-related medical conditions, accompanied by recommended lifestyle changes.
Many experts contend that, due to the significant potential of relapse, the therapy is often long-term.
This perspective is supported by pharmaceutical companies, who state that the results "underscore the persistent character of obesity," similar to managing diseases like high blood pressure.
User Testimonies
Users who have stopped the medication explain a powerful return of appetite.
"I experienced something that goes on and you're instantly ravenous," recalled a patient.
This challenge is worsened if individuals have not adopted permanent lifestyle or habit changes during treatment.
Widespread Use
Survey data suggest that millions of people in the UK have used weight-loss jabs in the past year, with demand remaining high.
- Adoption is greater among females than men.
- The middle-aged age group shows the highest usage rates.
- Many access the drugs through private healthcare rather than public health services.
Finally, experts caution that while these medications are effective tools for weight loss, they are not a magic cure and long-term success likely depends on ongoing behavioural management.
